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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Ursolic acid, Oxaliplatin
Phytochemical Name Ursolic acid (PubChem CID: 64945 )
Anticancer drug Name Oxaliplatin (PubChem CID: 9887053 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 192
Ref_1
Pair Name Ursolic acid, Oxaliplatin
Disease Info [ICD-11: 2B91.Z] Colorectal cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Activity CASP3 hsa836
Up-regulation Activity CASP8 hsa841
Up-regulation Activity CASP9 hsa842
Down-regulation Expression XIAP hsa331
Down-regulation Expression BIRC5 hsa332
In Vitro Model RKO Colon carcinoma Homo sapiens (Human) CVCL_0504
Result These observations suggested that a combination of UA and Oxa elicited synergistically anticancer effects in RKO cells and provided new evidence for potential application of UA and Oxa for CRC treatment.
Reversing Drug Resistance
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Combination Pair ID: 188
Ref_2
Pair Name Ursolic acid, Oxaliplatin
Disease Info [ICD-11: 2B91.Z] Colorectal cancer Investigative
Biological Phenomena Induction-->ROS generation
Gene Regulation Up-regulation Expression ROS1 hsa6098
Up-regulation Expression ROS1 hsa6098
Up-regulation Activity CASP3 hsa836
Down-regulation Expression ABCB1 hsa5243
Down-regulation Expression ABCC1 hsa4363
In Vitro Model HCT 8 Colon adenocarcinoma Homo sapiens (Human) CVCL_2478
SW480 Colon adenocarcinoma Homo sapiens (Human) CVCL_0546
Result Our study provided evidence that ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by ROS-mediated inhibition of drug resistance.
03. Reference
No. Title Href
1 Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells. Pharmazie. 2020 Jun 1;75(6):246-249. doi: 10.1691/ph.2020.0417. Click
2 Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance. Cancer Sci. 2018 Jan;109(1):94-102. doi: 10.1111/cas.13425. Click
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